Balneus

Australian Lefty on Politics, Governance, Science and Info Management

Prozac/SSRIs during pregnancy risks your child getting depression, bipolar et al

Posted by Dave Bath on 2008-07-26


Bottom line: before getting pregnant or during pregnancy, come off SSRIs (Selective Serotonin Re-uptake Inhibitors) e.g. prozac, fluoxetine: because in-utero exposure across the placenta "affects fetal development, resulting in cardiomyopathy and a higher vulnerability to affective disorders in a dose-dependent manner."

DO NOT CHANGE YOUR MEDICATION REGIME WITHOUT APPROPRIATE MEDICAL ADVICE.

So… depression is an affective disorder (as is bipolar and a host of others)… being treated for depression/anxiety/bipolar/etc/etc/etc increases the risk your baby will develop similar conditions later in life.  Depression is reported in 10%-16% of pregnancies, and SSRIs are the most commonly prescribed treatment.

BigPharma must be jumping for joy at this feedback loop!

More details of the paper over the fold, but first, BeyondBlue (a bipartisan initiative of the Australian, state and territory governments) is worth a visit if you think you, or a loved one, might be affected by depressive illnesses.

Placental transfer of SSRIs in mice is similar to humans, and…

clinical doses were applied to the (mouse) mothers during pregnancy, we found that the offspring suffered in a dose-dependent manner from a severe form of dilated cardiomyopathy and that surviving mice had severe behavioral abnormalities which may relate to anxiety disorders.

See Also/Notes:

  • Modulation of Serotonin Transporter Function during Fetal Development Causes Dilated Heart Cardiomyopathy and Lifelong Behavioral Abnormalities (doi 10.1371/journal.pone.0002782) or get the pdf.  PLoS One articles have a forum for each paper… look to the top right of the page, or use this link to view the "official" discussion.  No comments yet – it’s just hit my RSS.
     
  • BeyondBlue

    beyondblue is a national, independent, not-for-profit organisation working to address issues associated with depression, anxiety and related substance misuse disorders in Australia.

    beyondblue is a bipartisan initiative of the Australian, state and territory governments with a key goal of raising community awareness about depression and reducing stigma associated with the illness.

    beyondblue works in partnership with health services, schools, workplaces, universities, media and community organisations, as well as people living with depression, to bring together their expertise around depression.

  • The paper is in Eclectica (web version or RSS), but worth putting here because of the number of people probably affected, already, and in the future
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